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Brett Favre's Parkinson's Diagnosis Sparks Renewed Concerns Over Football's Brain Disease Link

Photo : AP

Hall of Fame quarterback Brett Favre's recent announcement regarding his Parkinson's disease diagnosis has reignited discussions about the potential links between contact sports and the risk of brain diseases. Favre disclosed his diagnosis during a congressional hearing on Tuesday, where he was addressing allegations of misusing taxpayer funds related to a welfare scandal in Mississippi. The conversation about his health surfaced as he mentioned a financial loss related to an investment in a company that claimed to be developing a breakthrough concussion drug.

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“I’m sure you’ll understand why it’s too late for me because I’ve recently been diagnosed with Parkinson’s,” Favre stated during his testimony. He highlighted the seriousness of his condition, which adds to the growing concerns regarding the long-term health effects of playing football.

Favre's career spanned two decades in the NFL, primarily with the Green Bay Packers, and he retired 13 years ago. In a 2022 interview with “The Bubba Army” radio show, he revealed that he believed he had suffered thousands of concussions throughout his playing days. "Every time my head hit the turf, there was ringing or stars going, flash bulbs, but I was still able to play," he recalled. "That’s what’s kind of frightening about the concussion thing. It’s the ones that seem minor that do the damage."

Sports that involve repetitive collisions, including football, boxing, and rugby, inherently carry the risk of concussions and other head injuries. Shannon Shaffer, a nurse practitioner at the Cleveland Clinic and liaison at Rune Labs, a neurology-focused analytics firm, explained, “We know that the brain can only take so much, and when there’s this kind of trauma—whether sports-related or not—repeated trauma to the brain is known to have long-term effects.”

Early research has established a probable connection between participation in collision sports and the development of Parkinson’s, as well as other neurodegenerative diseases like Alzheimer’s, amyotrophic lateral sclerosis (ALS), and chronic traumatic encephalopathy (CTE). Multiple studies indicate that sustaining even a single concussion can increase the likelihood of being diagnosed with Parkinson’s by more than 55%.

The NFL did not respond immediately to requests for comments regarding Favre's diagnosis and the broader implications of football on neurodegenerative diseases. A study published last year found that individuals with a history of playing football had a 61% higher likelihood of exhibiting Parkinson’s symptoms or being diagnosed with the condition. A similar study in 2018 indicated that the cumulative effect of repetitive head impacts from playing contact sports was associated with early indicators of Parkinson’s.

Hannah Bruce, an author of the recent study conducted at the Boston University Alzheimer’s Disease Research Center, noted the complexity of attributing Favre’s condition directly to football. "It’s hard to say whether it’s exactly because of football or if it just increased his risk or odds of developing Parkinson’s disease, or if there are other factors at play," Bruce said. "But we’re seeing more football players come forward. It definitely says something."

In 2022, neurologists who treated boxing legend Muhammad Ali concluded that his medical history supported a diagnosis of young-onset Parkinson’s disease, but they could not definitively link his condition to head trauma. Ali passed away in 2016, leaving behind a legacy that has sparked ongoing discussions about the health risks associated with combat sports.

Parkinson's disease is a neurodegenerative condition that leads to the deterioration of nerve cells in the brain, resulting in symptoms such as tremors, muscle stiffness, and impaired balance and coordination. Treatment options typically involve prescription medications or deep brain stimulation to alleviate symptoms. 

Repeated trauma to the brain is considered a potential trigger for Parkinson's, as it can induce inflammation that leads to the gradual death of nerve cells. However, several other factors contribute to the risk of developing the disease, including age, genetic predisposition, and exposure to certain environmental toxins.

Dr. Kevin Crutchfield, a neurologist at Hackensack Meridian Health, emphasized the importance of ruling out various factors before establishing a direct link between football injuries and Parkinson's disease. "The default isn’t, ‘Oh, you played football, you got Parkinson’s,’” he explained.

Despite the concerns, Crutchfield noted that among the tens of thousands of men who have played in the NFL, there hasn't been a significant surge in Parkinson’s diagnoses. However, the nature of the disease makes it challenging to diagnose, and symptoms can manifest long after an initial head injury.

Thor Stein, director of molecular research at Boston University’s CTE Center, stated that in some instances, CTE may trigger Parkinson's disease. Many former football players exhibit signs of CTE, which can only be definitively diagnosed post-mortem. "The more you get these repetitive hits to the head, the longer you are exposed to that, the greater your risk is for developing a number of different degenerative diseases, including both CTE and Parkinson’s disease," Stein said. He added that recent findings indicate that CTE can often cause symptoms resembling Parkinson's.

In a July study of brain donors diagnosed with CTE, Stein and his co-authors found that nearly 25% exhibited signs of parkinsonism. In a previous interview with TODAY in 2021, Favre expressed uncertainty about whether he had CTE.

Crutchfield advised that it is crucial for players to take breaks following head trauma to prevent more serious brain injuries, highlighting the need for greater awareness and management of concussion-related health risks in contact sports.

Sept. 25, 2024 11:39 a.m. 1025

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